Friday Pearl

On Living Better, Longer

Friday, March 29, 2019

Geroscience: The intersection of basic aging biology, chronic disease, and health.

Science is showing that while chronological aging is inevitable, biological aging is malleable. There’s a part of it that you can fight, and we are getting closer and closer to winning that fight.  ~The Buck Institute on Aging


Back in 1999, the Marin County, Calif., Buck Institute was the recognized pioneer in research on aging. Today they are the undisputed global leader in the field. Their research is focused on the biology of aging, yielding insights into age-related diseases before they start. 


The good news: The scientists at the Buck believe it's possible for people to enjoy their lives at 95 as much as they do at 25, and to achieve that, they are seeking a more comprehensive understanding of the biology of aging itself.  

Of the many areas of Buck's focus, exercise, nutrition, and metabolism get our attention. Once again they prove that lifestyle choices matter, as does the science behind them.

Nutrition and aging


Nutrition has important long-term consequences for health and aging that affect gene expression, as does calorie restriction. Therefore, it's vitally important to consume nutrient-dense calories and leave those high-calorie, nutrient-lacking junk foods on the supermarket and convenience store shelves. 


Something as simple and cost-effective as reasonable caloric restriction is also proving to be powerful protection for the aging heart and vasculature. Genomic research suggests exciting possibilities for a dynamic era of scientific investigation based on understanding the effects of nutrients in molecular-level processes in the body.


Thanks to the completion of the genome project, nutrition and health research is much more focused on the prevention of disease by optimizing and maintaining cellular, tissue, organ, and whole-body homeostasis.


This requires better understanding and ultimately regulating a multitude of nutrient-related interactions at the gene, protein, and metabolic levels, including the science and application of human transcriptomics (the study of RNA molecules and the validity of the DNA messages they send), proteomics (the study of an entire set of proteins expressed by a specific genome, cell, tissue, or organism at a certain time under defined conditions), and metabolomics (the scientific study of chemical processes involving metabolites).


These complex and exciting disciplines and their technologies are changing the paradigms of health and aging research. 


Ellen Troyer, with Spencer Thornton, MD, David Amess and the Biosyntrx staff 


For our Friday Pearl readers who might be interested. The Buck Institute is presenting their first ever free online live conference, Six Once-in-a-Lifetime Conversations. Session one is titled "The Age of Better Aging is Now." The course begins Tuesday, April 2, and runs through June 11, 2019, 3:pm ESD / 12:pm PDT. 

You can still register today. 

We would also like to suggest that our readers consider supporting philanthropic gifts to the Buck Institute. It has the ability to effect real change in biomedical research aimed at extending the healthy years of life.



Oxidants, antioxidants, and the degenerative diseases of aging. Ames, BN, Shigenaga MK, Hagen TM. Proceedings of the National Academy of Sciences USA (PNAS). September 1993 1; 90(17): 7815-7922 [abstract]

University of California at Davis Nutrigenomics Department