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Relief for Dry Eyes

Thursday, April 24, 2014

BioTears First!  

BioTears is an oral treatment for dry eyes designed and patented by the woman-led research team passionately determined to help those with dry eyes. This team opened the doors for dry eye nutritional therapy in 1998. BioTears includes the biochemically balanced natural ingredients required to enhance omega-6 and omega-3 fatty acid metabolism, while also addressing structure and function of all three layers of the tear film.

•    Millions of doses safely have been used by satisfied repeat customers.
•    BioTears are manufactured to FDA Good Manufacturing Practice standards.
•    BioTears carry a 60-day full money back guarantee. 

BioTears has been clinically suggested to improve the tear chemistry and health of the ocular surface in less than 28 days on more than 70 percent of dry eye patients studied. 

BioTears has been clinically suggested, through slit lamp observation, Rose Bengal staining, and lisemine green staining to improve the health of the ocular surface.

BioTears has been clinically suggested to extend tear break-up time (TBUT).

BioTears has been clinically suggested to increase aqueous output through the use of both Zone-Quick and Schirmer's tests.

BioTears has been clinically suggested to increase tear lactoferrin levels.

BioTears has been clinically suggested to decrease tear film inflammatory markers, interleukin 1 (IL-1 ) and IL-6.

Tens of thousands of satisfied BioTears customers strongly suggest, with every monthly repeat order, the very real subjective data that further proves BioTears' efficacy.                                

BioTears patented formulation

While developing a tear-specific formula for oral administration, Biosyntrx included the nutrient co-factors suggested necessary to address dry eye syndrome by physiologic rather than pharmacological means. These ingredients are designed to work synergistically rather than individually, and are suggested in published scientific literature to effectively address the inflammatory process responsible for most dry eye syndrome. They also enhance and restore function to the glands involved in all three layers of the tear film.  

Tear film structure and function are critical for optimal vision for multifocal intraocular lens recipients. 

Clinical studies have suggested that the omega-6 short chain fatty acid gamma-linoleic-acid (GLA) and the supporting nutrient co-factors included in BioTears Oral Gel Caps (vitamins C, B6, and the mineral magnesium) may restore normal production of lubricants in the eyes via the delta-6-desaturase conversion to the mucosal-tissue -specific, anti-inflammatory prostaglandin E1 (PGE1).  

The source of omega-6 fatty acids is black currant seed oil because it's by far the most chemically stable of the three oils that include GLA (borage, evening primrose, and black currant seed oil).

BioTears also addresses dryness in other parts of the body including mucous membranes of the mouth, vagina, and interior body surfaces such as joints and synovial membranes.  

Pharmaceutical-grade cod liver oil is the source of omega-3 EPA/DHA, which is germane to the formulation. It serves as a brilliant source of natural vtamins A and D, necessary for the base layer of the tear film.  

Cod liver oil is also a metabolic gateway boost to the downstream conversion of potent omega-3 fatty acids to the anti-inflammatory PGE3, while also preventing inappropriate omega 6 arachidonic acid cleavage via the delta-5-desaturase enzyme (D5D). 

Vitamin E, specifically gamma tocopherols, is suggested in peer-reviewed literature to prevent oxidation by stabilizing fatty acids and inhibiting COX-2 enzyme activity that promotes inflammatory response. 

Curcumin is suggested in peer-reviewed literature to appropriately block omega-6 fatty acids from metabolizing to the pro-inflammatory PGE2 and IL-1. 


Curcumin is a natural COX-2 inhibitor with similar chemical properties to ibuprofens Motrin and Advil (NSAIDs). The difference is curcumin does not inhibit production of the COX-1 enzyme that is necessary to protect the stomach lining. 

Vitamin C is suggested in peer-reviewed literature to enhance the production of IgE concentrates in tears, the first line of basophil and mast cell defense against invading pathogens and allergens that frequently cause dry eye symptoms.

Green tea is included to modulate osmolarity, one of the causative factors in dry eye, resulting in inflammation and subsequent cell damage. 

Lactoferrin is suggested in peer-reviewed literature to increase the level of iron-binding proteins to better inhibit viral and bacterial infections and to balance other tear lipocalins (family of proteins that transport small hydrophobic molecules) that modulate the surface tension of the tear film and affect the comfort of the contact lens wearer.

Lactoferrin taken orally appears to survive absorption in the stomach by converting to a very small molecule called lactoferricin, which can easily find its way into secretory tissue including the eyes.

Lactoferrin background

Lactoferrin is produced in the tear film by the lacrimal gland and by neutrophils that constitute the first line of defense against infection. Neutrophil apoptosis (programmed cell death) signals the macrophage to clean up debris from wound sites, including surgically induced wounds (LASIK).

BioTears Oral Gel Caps are designed to help inhibit LASIK- induced dry eye by supporting post-surgical wound healing response, enhancing lacrimal and meibomian gland output, as well as enhancing the post-op acetylcholine neurotransmitter blink response. 

Ellen Troyer, with Spencer Thornton, MD, and the Biosyntrx staff

Biosyntrx strongly believes that appreciation, exploration and commitment to science, art, music, and humanities add significantly to the global greater good and are important parts of the intellectual whole. 


The really good news is that BioTears' outstanding results are achieved without popping excessive amounts of fish oil. Recent peer-reviewed science suggests that excessive supplemental fish oil may increase the risk of adverse health outcomes, while also depleting our seas of pelagic fish needed for future generations.  



  • Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Barabino S, Rolando M, Camicione P, Ravera G, Zanardi S, Giuffrida S, Calabria G. Cornea. 2003 Mar;22(2):97-10 [abstract 

  • Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. Wu D, Meydani M, Leka LS, Nightingale Z, Handelman GJ, Blumberg JB, Meydani SN. American Journal of Clinical Nutr. 1999 Cot;70(4):536-43. [abstract]

  • Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN, Chilton FH. J Nutr. 1997 Aug;127(8):1435-44. [abstract 

  • Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C. Horrobin DF, Campbell A. Med Hypotheses 1980 Mar;6(3):225-32 [abstract]

  • The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome. Szodoray P, Hovath IF, et al. Rheumatology 2009 Nov 27 [abstract]

  • A compositional based model for the tear film layer. McCulley JP, Shine W. Trans Am Ophthalmol Soc. 1997;95:79-88; discussion 88-93. [abstract 

  • Impact of antiandrogen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. Sullivan BD, Evans JE, Krenzer KL, Reza Dana M, Sullivan DAJ Clin Endocrinol Metab. 2000 Dec;85(12):4866-73. [abstract 

  • Identification by gas chromatography/mass spectrometry of long-chain fatty acids and alcohols from hamster meibomian glands using picolinyl and nicotinate derivatives. Harvey DJ. Biomed Chromatogr. 1989 Nov;3(6):251-4 [abstract]

  • Vitamin E prevents changes in the cornea and conjunctiva due to vitamin A deficiency.Fujikawa A, Gong H, Amemiya T. Graefes Arch Clin Exp Ophthalmol. 2003 Apr;241(4):287-97. [abstract 

  • Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Tei M, Spun-Michaid SJ, et al. Invest Ophthalmol Vis Sci. 2000 Jan;41(1):82-8. [abstract 

  • Lacrimal gland uptake and metabolism of ascorbic acid. Dreyer R, Rose RC. Proc Soc Exp Biol Med. 1993 Feb;202(2):212-6. [abstract]

  • Relationship between goblet cell density and tear function tests. Yeo AC, Carkeet A, Carney LG, Yap MK. Ophthalmic Physiol Opt. 2003 Jan;23(1):87-94. [abstract 

  • Pro- and Anti-inflammatory Forms of Interleukin-1 in the Tear Fluid and Conjunctiva of Patients with Dry-Eye Disease Abraham Solomon, Dilek Dursun, Zuguo Liu, Yuhuan Xie, Angelo Macri and Stephen C. Pflugfelder. Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2283-92. [abstract 

  • Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH. J Nutr. 2000 Aug;130(8):1925-31. [abstract 

  • Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells Jiang Q, Elson-Schwab, Courtemanche C, Ames BN Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11494-9. [abstract]

  • Safety and Anti-Inflammatory Activity of Curcumin: A Component of Turmeric (Curcuma longa). Chainani-Wu N. Altern Complement Med 2003 Feb;9 (1): 161-8 [abstract]

  • Pseudokeratoconus caused by rosacea. Dursun D, Piniella AM, Pflugfelder SC. Cornea2001 Aug;20(6):668-9 [abstract]

  • Tear lipocalins: potential lipid scavengers for the corneal surface. Glasgow BJ, Marshall G, Gasymov OK, Abduragimov AR, Yusifov TN, Knobler CM Invest Ophthalmol Vis Sci 1999 Dec;40(13):3100-7 [abstract 

  • The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G. HeS, McEven AR, blewell SA. Biochem Pharmacol 2003 Mar 15; 65 (6): 1007-15 [abstract]

  • Components responsible for the surface tension of human tears. Nagyova B, Tiffany JM.Curr Eye Res 1999 Jul;19(1):4-11 [abstract]

  • Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NFkappa B. Haversend L, Ohlsson BG, Hahn-Sone M. et al. Cell Immunol. 2002 Dec; 220 (2); 83-95 [abstract 

  • Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: identification of its active domain. Miyacchi H, Hashimoto S, et al. Cell Immunol. 1998 Jul 10;187(1):34-7. [abstract 

  • What is dry eye and what does it mean to the contact lens wearer? Foulks, GN. Eye Contact Lens. 2003 Jan;29(1 Suppl):S96-100; discussion S115-8, S192-4. [abstract]

  • A multi-centre study of lapsed contact lens wearers. Ophthalmic Physiol Opt. 2002Nov;22(6):516-27. [abstract]

  • Lipid, lipase and lipocalin differences between tolerant and intolerant contact lens wearers.Glassom M, Stapleton F. Willcox M Curr Eye Res. 2002 Oct; 25 (4); 227-35 [abstract 

  • Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. Macri A, Giuffrida S, et al. Graefes Arch Clin Exp Ophthalmol. 2003 May 27 [epub ahead of print] [abstract]

  • Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells. Cavet M, Harrington K, et al. Molecular Vision 2011: 17:533-542 [abstract]

  • Influence of corneal refractive surgery on the lacrymal film. Pisella PJ, Godon C, Auzerie O, Baudouin C. Fr Ophtalmol 2002 Apr;25(4):416-22 [abstract 

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