Support for Dry Eyes
- Invented by a women-led science team passionately determined to support ocular surface health
- Biochemically balanced natural ingredients that support fatty acid metabolism and the structure and function of all three layers of the tear film.
- Millions of doses safely used by satisfied repeat customers
- Manufactured to FDA Good Manufacturing Practice standards.
- 60-day full money back guarantee
- You have nothing to lose but your dry eyes.
BioTears First - the healthy tear film standard of care.
It's suggested in peer-reviewed literature that these specific nutrients support normal structure / function production of lubricants in other affected parts of the body, such as mucous membranes of the mouth and vagina, and interior body surfaces such as joints and synovial membranes.
We recommend you scroll up and visit the BioTears Ingredient Scientific
Rationale link for more information. The manufacturing link is at the
bottom of every page.
Recommended dosage: Four oral capsules per-day; two with each morning and evening meal.
Precautions: Coumadin patients should consult their primary care physician when taking this formulation. Pregnant or lactating women, or individuals with medical conditions should also consult a physician before using.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, or treat any disease.
Dry Eye Overview
Was I in last night?
I remember a book
Pathology of the three-layer tear film:
The Mucus Layer - the closest layer to the corneal epithelium. It is produced by the conjunctival goblet cells, and is absorbed by the corneal surface glycoproteins, creating a hydrophilic surface. Mucin deficiency, or mucopolysaccharide abnormalities, can lead to poor wetting or glycation of the corneal surface with subsequent desiccation and epithelial damage, even in the presence of adequate aqueous tear production.
The Aqueous Layer - the layer between the mucous and lipid layers. It is secreted by the lacrimal gland and incorporates all water-soluble components of the tear film. It also comprises 90% of the tear thickness. The aqueous layer provides moisture and supplies oxygen and important nutrients to the cornea.
The Lipid Layer - the most superficial layer. It is produced by the Meibomiam glands with contributions from the glands of Zeis and Moll of the eye lids. The secretion is an oily material, which is fluid at body temperature and retards evaporation of the aqueous layer and lowers surface tension, thereby allowing the tear-film to adhere to the eye's surface. Androgen receptors are located in both the lacrimal and meibomian glands. A decrease in circulating androgen hormones can result in loss of the oil laye, exacerbating the evaporative tear loss.
The Blink Reflex renews the tear film by delivering aqueous and lipid to the tear film and sweeping away debris. The normal blink interval is about 5 seconds under normal conditions. The tear film is typically stable for about 10 seconds. Tears are normally evaporated or forced out through the nasolacrimal ducts in the inner corner of the eyes on blinking.
The Root Causes of Dry Eyes
Many different things cause dry eyes. The normal aging of tear glands, as well as extended use of contact lens, environmental pollutants, prescription drugs, refractive surgery, nutrient deficiencies and other issues can cause disruption in the tear production and retention process.
The typical symptoms of the dry eyes include dryness, grittiness, irritation, difficulty reading for long periods of time, burning and even the apparent contradiction of excessive tearing or watering. In extreme cases of dry eye, patients may become unusually sensitive to light, experience severe eye pain, and start to notice diminished vision. Successful treatment may be needed to avoid permanent damage.
Blepharitis can often cause dry eye symptoms due to inflammation of the eyelid margins, which is caused by a bacterial infection (Staphylococci). This condition can compromise the quality of the tear film causing tears to evaporate more quickly. The bacteria produce waste material that can cause a mild toxic reaction leading to chronic red, irritated eyes.
Extended Contact Lens Wear can result in dry eye from corneal oxygen and nutrient deficiency. Protein build-up on contact lens can produce a breeding ground for bacterial growth and surface roughness, further contributing to inflammatory changes. Some contact lens solutions contain preservatives that can also cause chemical irritation of the corneal surface and result in dry eye symptoms.
LASIK Surgery temporarily disrupts the ocular surface/lacrimal gland unit. Also, during LASIK, roughly 60-70% of the superficial nerve fibers in the cornea are severed, which reduces sensation and affects aqueous tear production and delays wound healing. With compromised sensation, the blink rate can slow to the point that the tear film breaks up before the next blink can reconstitute. Though this condition usually clears up after a few months, it may result in mild to severe dry eye syndrome for several months after surgery.
Age - Dry eyes are common in 75% of people over age 65. Tear volume decreases from age 18 as much as 60% by age 65.
Hormonal changes cause decreased tear production brought on by pregnancy, lactation, menstruation, and menopause.
Computer Use causes most people to blink less frequently (about 7 times per minute vs. a normal rate of around 22 times/minute). This leads to increased evaporation along with the fatigue and eye-strain associated with staring at a computer monitor. Any task requiring a great deal of concentration can result in decreased blink rate.
BioTears Generally Regarded as Safe (GRAS) Ingredient Rationale
Artificial tears flush out debris, dilute substances trapped in the tear film, and increase tear clearance. They do not, however, support all the factors critical for the maintenance and repair of the ocular surface, nor do they address tear film structure and function or the supporting role it plays in visual acuity.Oral administration of specific omega 6 essential fatty acids that contain sufficient amounts of gamma-linolenic-acid (GLA) support ocular surface and tear film health. We use Black Currant Seed Oil as our source of omega 6 GLA because it is more stable than either Borage Oil or Evening Primrose Oil. We do not use Flax Seed Oil because it is the most unstable of the essential fatty acid oils, and the small amount of Omega-6 fatty acids it includes does not easily convert to gamma linolenic acid (GLA).
The nutrient co-factors included in BioTears Oral Gel Caps support normal production of lubricants in the eyes and other affected parts of the body, such as mucous membranes of the mouth and vagina, and interior body surfaces such as joints and synovial membranes. (4)
In developing a tear-specific formula for oral administration, Biosyntrx included the nutrient co-factors that support structure / function of lubricant production by physiologic rather than pharmacological means. These nutrient ingredients are designed to work synergistically rather than individually.
Essential fatty acid mechanism of action metabolic chart removed to meet FDA-monitored federal regulations.
Omega 6 fatty acids convert to the series one prostaglandins (PGE)1 via the linoleic-acid (LA) to
gamma-linolenic-acid (GLA) to dihomo-gamma-linolenic-acid (DGLA) to PGE1. To help ensure this science-based conversion, we
included the nutrient co-factors, vitamins A, C, B6, and magnesium. The
delta-six-desaturase (D6D) enzyme necessary for this conversion is too
easily disrupted by alcohol, aging, smoking, elevated cholesterol
levels, and environmental factors without these additional nutrient
co-factors, which are also suggested to modulate healthy goblet cell production
and neurotransmitter blink response.
Pharmaceutical grade cod liver oil, as a source of Omega 3 EPA/DHA is germane to the formulation. It serves as a health-promoting metabolic gateway boost to the downstream conversion of the Omega 3 to the anti-inflammatory PGE3.
Vitamin E, specifically gamma tocopherols, stabilizes the EFAs.
Curcumin is included to support ocular surface health.
Vitamin C, as ascorbic acid and fat-soluble absorbyl palmitate,supports fatty acid metabolism.
Lactoferrin supports structure / function levels of iron binding proteins that support inhibition of viral and bacterial biofilm formation, as well as supporting other tear lipocalins (family of proteins that transport small hydrophobic molecules that support modulation of the surface tension of the tear film that can affect the comfort of the contact lens wearer.
Background: Lactoferrin is naturally produced in the tear film by neutrophils that constitute the "first line of defense" against infection. Neutrophil apoptosis (programmed cell death) signals the macrophage to clean up debris from wound sites, including surgically induced wounds (LASIK).
Green Tea is included to support ocular surface health.