Macula Complete
Potent Macula and Full Body Protection
- Ultimate nutrition for eye and body health and renewed energy
- Designed to protect the retina and full body from degenerative disease
- 180 capsule count per bottle
- Includes the vitamins, minerals and plant-based nutrients in the ARED, LAST and Mitotropic Compound studies, and far more (Omega-3 fatty acids from fish oil are sold separately as ZoOmega-3 for optimal product stability).
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Addresses DNA protection, gene signaling, mitochondrial energy production and the inflammatory processes associated with macular degeneration and all retina disease including glaucoma and diabetic retinopathy.
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Recommended dosage: six capsules a day, three with breakfast and three with dinner
- Millions of doctor-recommended doses safely used by satisfied consumers
- Made in USA to FDA Good Manufacturing Practice Standards (GMP) and presented in vegetable capsules for maximum absorption
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60-day full money back guarantee - without exception
A Wise Decision!
General Overview of Macula Complete
Macula Complete is a high-energy premium broad-spectrum dietary
supplement of vitamins, minerals and antioxidant phytochemicals designed
to support optimal body and retinal function. When you take Macula
Complete you do not need additional multiple vitamin supplements. Macula Complete is Made in the U.S.A in a NSF GMP registered facility.
Macula Complete includes the nutrients used the three major studies on nutrition as it relates to eye health.
- ARED study
- Lutein Antioxidant Supplement Trial (LAST)
- Phototrop Study (with the exception of Omega-3 fatty acids, which we present as a stand alone product, ZoOmega-3, to ensure fatty acid stability.
The nutrients included in these studies inhibited AMD disease progression in the study participants. We also added efficacious amounts of Alpha Lipoic Acid, CoQ10, and Acetyl-L-Carnitine, which have been suggested in peer-reviewed studies to support the mitochondria, as well as to support production of cellular (ATP) energy.
Recommended dosage: Take 6 capsules per day, 3 with each morning and evening meal.
Precautions: Pregnant and lactating women should consult their physician before taking this formulation. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, or treat any disease.
Age Related Macular Degeneration
Scientific Rationale Supporting Macula Complete
We are very appreciative of the ARED study and its effect on the eye care professionals understanding of the relationship between nutrients and macular degeneration. However, it is noted in the body of the ARED study that 57% of the study participants were already taking antioxidant vitamins before enrolling in this study, and an additional 13% who were not taking supplements chose to take a multi-vitamin mineral supplement on top of the ARED formulation. Therefore, almost 70% of those in the trial also concurrently took an additional RDA-focused multiple.
The Biosyntrx
scientists believes it prudent to offer a potent multiple for the A
Macula Complete is presented in capsule form to assure bioavailability for the older consumer.
Given the vast amount of science that now supports daily intake of Omega-3 EPA and DHA, we recommend that our concentrated fish oil ZoOmega3 (300 mg EPA and 200 mg DHA per capsule) be taken with each daily dose of Macula Complete.
Vitamin A at 2,500 IU
in Macula Complete as retinyl palmitate, guarantees adequate retinol for
night vision, cornea health, wound healing, immune protection and
appropriate cellular differentiation. Vitamin A should always be
presented with zinc and taurine, since they all three play an important
role in optimal photoreceptor function. A number of published studies
link excessive amounts of Vitamin A as retinol to hip fracture in older
people. Macula Complete Vitamin A does not exceed the
B vitamins include
potent amounts of the full-spectrum of the B-Complex. They are included
in Macula Complete to prevent DNA damage which can lead to
inappropriate gene transcription, and to control blood levels of
homocysteine that has been suggested in published studies to increase
the risk of dry A
Vitamin E is presented
in Macula Complete as 30 IU of natural D-alpha tocopherol, primarily
from mixed tocopherols, as well as 30 mg of Vitamin E tocotrienols to
maintain biochemical balance of the 8 different parts of vitamin E:
alpha, beta, gamma and delta tocopherols and tocotrienols. The amount of vitamin E listed on a
supplement fact box in the vitamin section only refers to the amount of
alpha-tocopheral, not the amount of the complete spectrum of vitamin E.
Full-Spectrum Minerals are balanced to
provide proper bio-electrical responses at the cellular level. This is a
major issue for proper enzymatic function in the human body, including
the eye. These minerals include Calcium,
Magnesium, Selenium, Boron, Copper, Manganese, Chromium, Vanadium, and
Molybdenum.
Zinc at 25 mg is included in Macula Complete. It is chleated with monomethionine for optimal absorption. This zinc is balanced with small amounts of copper and manganese to produce intracellular super-oxide dismutase (SOD) and extracellular manganese super-oxide dismutase (MnSOD), which is necessary to neutralize singlet oxygen and super oxide free radicals. Excessive copper intake is linked to angiogenesis.
Carotenoids are a scientifically balanced mixture of beta and alpha carotenoids, 1 mg of lycopene, 16 mg of FloraGlo lutein plus 4 mg of ZeaGold zeaxanthin, which strengthen the macula and has been suggested to lower the risk of developing certain tes of cancers. New science suggests that the central macula has a distinct preference for zeaxanthin. Macula Complete does not included beta carotene. It is considered safe for those who still smoke and those who have ever smoked or been exposed to second-hand smoke.
Phytochemical Antioxidant anthocyandins - grape seed, bilberry and ginkgo biloba provide potent antioxidant protection from free radical damage in the entire body and the eyes.
Bioflavnoids, (hesperidin, quercetin, and rutin) strengthen the vascular system, which plays an important role in transporting proper nutrients to every organ in the body including the eye.
Trans-Resveratrol is included at the 100 mg level to enhance mitochondrial function, improve insulin sensitivity, reduce inflammation and protect against toxic effects of high-fat diets. Trans-resveratrol is suggested in a number of studies to mimic caloric restriction benefits linked to protection of chromosome caps, or telomeres, that deteriorate with age. Longer telomeres are associated with both longer lives and healthier aging.
Green Tea is included at the 100 mg level to reduce the risk of cancer development and progression. Green Tea is rich in catechin polyphenols, particularly epigallocatechin gallate (EGCG). EGCG is suggested to lower LDL cholesterol levels, and inhibit abnormal formation of blood clots.
Taurine is included to retard the progressive visual field reduction in retinitis pigmentosa and as the universal carrier of lipid soluble vitamins. Taurine intake is suggested to play a significant role in maintaining fluid balance in the eye.
Carnosine is included to slow the progression of cellular cross-linking associated with cataract formation.
Mitotrophic compounds, Lipoic Acid, CoQ10 and Acetyl-l-Carnitine to delay brain mitochondrial decay and aging. They are also suggested to slow the progression of macular degeneration and memory loss in a number of studies. These nutrients boost ATP cellular energy.
References:
MAJOR AMD NUTRITION STUDIES
B Vitamin Studies
Hyperhomocysteinemia and vitamin score: correlations with silent brain ischemic lesions and brain atrophy.Polyak Z, Stern F. Dement Geriatr Cogn Disord. 2003;16(1):39-45. [abstract]
Betaine supplementation lowers plasma homocysteine in healthy men and women.Steenge GR. Verhoef, P, et al. J Nutr. 2003 May;133(5):1291-5. [abstract]
Hyperhomocysteinemia in Japanese patients with convalescent stage ischemic stroke: Effect of combined therapy with folic acid and mecobalamine.Sato Y, Kaji M, et al. J Neurol Sci 2002 Oct 15;202(1-2):65 [abstract]
Vitamins for chronic disease prevention in adults: scientific review.Fairfield KM, Fletcher RH. JAMA. 2002 Jun 19;287(23):3116-26. Review. [abstract]
Hyperhomocysteinemia and retinal vascular occlusive disease.Abu El-Asrar AM, Addel Gader AG, et al. Eur J Ophthalmol. 2002 Nov-Dec;12(6):495-500. [abstract]
Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes.Looker HC, Fagot-Campagna A Diabetologia. 2003 May 28 [Epub ahead of print] [abstract]
Vitamin C Studies
Ascorbic acid spares alpha-tocopherol and decreases lipid peroxidation in neuronal cells.Lix, Huang J, May JM. Biochem Biophys Res Commun 2003 Jun 6;305(3):656-61. [abstract]
Vitamin D Studies
Vitamin D and bone health in postmenopausal women.Malabanan AO, Holick MF. J Womens Health 2003 Mar;12(2):151-6. [abstract]
Vitamin D receptor alleles, periodontal disease progression, and tooth loss in the VA dental longitudinal study.Inauaki K, Krall EA, et al. J Periodontol. 2003 Feb;74(2):161-7. [abstract]
Risk of mortality with vitamin E supplements: the Cache County study. Hayden KM, Welsh-Bohmer KA, et al. Am J Med. 2007 Feb;120(2): 180-4 [abstract]
The relationship between serum trace element changes and visual function in heavy smokers.Uz E, Sabin S, Hepsen IF, et al. Acta Ophthalmol Scand 2003 Apr;81(2):161-164. [abstract]
Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson's disease.Brewer GJ. Exp Biol Med (Maywood) 2001 Jul;226(7):665-73 [abstract]
Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells.Hyae Jung Hyun, Joon Hong sohn, et al. Investigative Ophthalmology and Visual Science. 2001;42:460-465. [abstract]
Carotenoid Studies
Effects of 4 y of oral supplementation with beta-carotene on serum concentrations of retinol, tocopherol, and five carotenoids.Nierenberg DW, Dain BJ, et al. Am J Clin Nutr 1997 Aug;66(2):315-9. [abstract]
Bioavailablility of elderberry anthocyanins.Milbury PE, Cao G, at al Mech Ageing Dev 2002 Apr;123(8):997-1006 [abstract]
Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma.Quaranta L, Bettelli S, et al. Ophthalmology 2003 Feb;110(2):359-62; discussion 362-4. [abstract]
Influences of taurine and micronutrients on nitric oxide synthase expression and cGMP content in rat retina.Mi MT. Ahu JD, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2000 Nov;16(4):343-6. Chinese. [abstract]
The role of diet in cognitive decline.Solfrizzi V, Panza F, et al. J Neural Transm 2003 Jan;110(1):95-110 [abstract]
Taurine as a universal carrier of lipid soluble vitamins: a hypothesis.Petrosian AM, Haroutounian JE. Amino Acids. 2000;19(2):409-21. Review. [abstract]
Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-l-carnitine, n-3 fatty acids, and coenzyme Q10. Feher, J, Kovacs B, et al. Ophthalmologia 2005 May-June:219(3): 154-66. [abstract]
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QWhat is the source of lutein in Oculair and Macula Complete?
The lutein we include in Macula Complete and Oculair (FloraGLO) is the best available. It is 20% crystalline liquid suspended in corn oil, which is purified from marigold petal extract using a very special patented process. This type of lutein is far more bioavailable than the 5% dry form used by most multiple manufacturers. Unlike lutein esters, this lutein is chemically identical to lutein found in spinach, kale, collard greens, and other green leafy vegetables in our diet. We take the extra time to run our powder multiple formulation through dryers (this allows us to use the 20% crystalline liquid) before encapsulating to ensure the best absorption rate for our customers.
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QJust what is the macula?
The macula is the most sensitive area in the retina. It is located in the center of the back of the eye where images are focused by the lens system of the eye. Macula means spot, and since the macula is yellowish in color it is called the macula lutea. Lutea means yellow in Latin. Lutein, an important carotenoid antioxidant, is important in the treatment of macular degeneration. Lutein is found in high concentrations in both spinach and kale.
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QWhy did my eye doctor suggest that I start with one half dose of Macula Complete for the first two weeks and then build up to the full dosage the second two weeks?
Macula Complete is a concentrated super-potent multiple vitamin/minerar/antioxidant, which can produce an immediate detox effect in some people - these are usually the people who are the most nutrient deficient. It is important that you not discontinue taking Macula Complete if you get slight headaches or upset stomachs. Most people easily adjust to the formulation by starting with one or two capsules a day (always with food) and then slowly working up to the six-per-day full dosage.
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QWhy does Macula Complete contain such expensive nutrients like acetyl-l-carnitine, CoQ10 and large amounts of lipoic acid? The other mucula formulations do not include these nutrients.
All of these nutrients have specifically been shown to dramatically improve cellular mitochondria function in histopathologic studies. Improved mitochondria function provides beneficial effects in preventing and treating Age Related Macular Degeneration (AMD).
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QDoes excessive zinc supplementation increase the risk of prostate cancer?
The July 2003 Journal of The National Cancer Institute reported that men who supplement with 100 mg of daily zinc are at twice the risk of advanced prostate cancer, as are men who supplement with amounts that excessively exceed the Institute of Medicine safe upper limits of zinc for more than 10 years. This data was collected from a 14 year follow-up survey of 46,974 health professionals. Biosyntrx multiples are designed for long-term use and include no more than 40-50 mg of zinc, as monomethinonine, which is properly balanced with the full-spectrum of minerals for optimal safety.
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QIs Macula Complete appropriate for smokers or former smokers?
After lengthly study of both the ATBC and CARET beta carotene/lung cancer trials, the Biosyntrx Scientific advisors are confident that Oculair and Macula Complete are safe for smokers and former smokers. Our research and design team carefully studied the beta-carotene trials from the mid 1990s before including a very small amount of beta-carotene in our multiple formulations to address specific issues of singlet oxygen formation and diseases of the eye. Biosyntrx multiples include less than one (1) mg beta-carotene, which is appropriately balanced with a complete host of carotenoids and other phytonutrient antioxidants, including 400 IUs of mixed tochpherol Vitamin E and 500 mg of Vitamin C, which are both vital to healthy lungs for all who smoke or have smoke damaged lungs. For more information on this subject visit the Friday Pearl sectio
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QDoes Macula Complete Include Both Lutein and Zeaxanthin?
Absolutely. Macula tissue preference for these two zanthophylls has been proven to our scientific advisors satisfaction. Macula Complete is the only full-spectrum multiple formulations available to the AMD patients that includes 10 mg of the highest concentrate FloraGlo Lutein, appropriately balanced with 4 mg of pure Zeaxanthin, which is the preferred carotenoid of the central macula. Biosyntrx does not make zeaxanthin label claims for the amount of zeaxanthin or meso-zeaxanthin that might be converted from supplemental lutein, as do most other companies.
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QWhat does the word "COMPLETE" mean in the name Macula Complete?
The Macula Complete vitamin/mineral/antioxidant formula is designed to meet the needs of the delicate neurovascular structures in the central, most sensitive part of the retins. In addition to the specific vitamins, minerals and antioxidants needed for retinal health, Macula Complete contains effective amounts of the nutrients that are lacking in most other available products. In other words, when you take Macula Complete, you do not need to take any other multiple vitamin product. Remember, what's good for the eyes is good for the whole body.
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QGiven the high-smoking rate profile of AMD patients, and the
cellular competition for transport space of the carotenoids, why would
AMD formulations like Bausch&Lomb's PreserVision and the copy cat companies include 25,000 IUs of beta-carotene in their formulations?
We assume these formulation designers, and the companies who copy them, do not monitor AMD patient lifestyle profiles, or recent vitamin A and carotenoid science. It concerns us that the PreserVision AMD consumers don't always understand that to protect their vascular system and their macula, they need to take additional supplemental antioxidants, vitamins, minerals and xanthophylls that are not included in the PreserVision formulation.
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QI've been told that supplemental bilberry and Ginko biloba might increase the risk of retinal bleeding for patients with wet macular degeneration. Is this so?
This is a great question and one that is ask by a number of AMD patients. It's important to understand that although both of these nutrients tend to slightly thin the blood, they also dramatically improve ocular microcirculation and protect the vascular endothelium, as well as inhibit collegen destruction and decrease capillary fragility. Retinal bleeds are normally caused by capillary fragility, not thin blood. Biosyntrx multiple formulations also include an antioxidant bioflavinoid complex that includes quercetin, rutin and hesperidin, which further strengthen the capillaries that feed the eye and the brain, as well as the fragile capillaries formed during subretinal neovascularization.
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QShould beta-carotene be used as the primary source of supplemental
Vitamin A and does beta-carotene interfere with Lutein absorption?
Not in the opinion of the Biosyntrx team. Pre-formed Vitamin A, or retinol, is absolutely essential for eye health, wound healing, and proper immune function. Beta-carotene, as pro-formed Vitamin A, only attempts to metabolically convert to retinol when and if the vitamin A cellular stores are retinol deficient. The beta-carotene/retinol conversion becomes more and more difficult with the aging process. Recent science suggests that beta-carotene converts to retinol at less that half the rate once published. Excessive amounts of supplemental hydrocarbon antioxidant carotenoids, which include beta-carotene, are also thought to compete for transport space with the carotenoid xanthophylls like lutein and zeaxanthin, which are particularly important to the prevention of degenerative disease of the macula. Two large-scale studies, CARET and ATBC, su
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QIs Macula Complete safe for people who take blood thinners like Coumadin?
Yes it is safe. However, we recommend that Coumadin patients have their clotting time checked on on a regular basis. Essential Fatty Acids, fish oil, vitamin E, bilberry, and Ginko biloba are all reported to slightly reduce clotting time - therefore, it may be necessary to slightly lower the amount of prescription Coumadin taken on a daily basis. We do not recommend patients ever reducing the amount of Coumadin they take without physician knowledge.
