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Zeaxanthin4

Zeaxanthin4

Zeaxanthin4

Supplement Facts
 

Central Macula Protection

  • 4 mg of zeaxanthin combined with 25 mg of fat soluble Vitamin C
  • Increases central macula protection from UV damage.
  • Supports neural tissue and the immune system
  • 180 capsule count per bottle
  • Recommended dosage: 1 capsule daily
  • Manufactured in NSF certified facility to FDA Good Manufacturing Practice Standards (GMP) and presented in vegetable capsules for maximum absorption.
  • Sold with full money back guarantee
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Zeaxanthin Product Information

Zeaxanthin is one of the two carotenoids contained within the retina. Within the central macula, zeaxanthin is the dominat component. Zeaxanthin-4 includes four mg of ZeaGold zeaxanthin with 25 mg of fat soluble ascorbyl palmitate Vitamin C. 
 
Not all supplemental zeaxanthin is the same.
 
The ZeaGold natural zeaxanthin in Biosyntrx Zeaxanthin-4 comes from Paprika Peppers grown in the U.S.A. Paprika Peppers have a higher concentration of pure zeaxanthin that any other plant source.  ZeaxGold is a raw ingredient from Kalsec, a premiere supplier of U.S. grown herbs and plant-based nutritionals. The Paprika Peppers are grown on on a Kalsec owned TX  farm and processed at a Kalsec owned U.S.A  facility.  Zeaxanthin-4 is manufactured in a U.S.A. NSF/GMP facility, as are all Biosyntrx formulations.  

Zeaxanthin Overview

Zeaxanthin is suggested in peer-reviewed literature to be the central macula preference over lutein. Dietary and supplemental Zeaxanthin is preferentially deposited at the center of the macula. If the diet is deficient in zeaxanthin, which most diets are, and supplemental zeaxanthin is not available, the macula preference for zeaxanthin is so strong the body will convert a small amount of dietary lutein to a similar molecule called meso-zeaxanthin in an attempt to supply the eye with pigment that best protects the macula. Meso zeaxanthin is not found anywhere in the body, except in the eye.

Scientific Rationale Behind Zeaxanthin

Scientific research has established that dietary zeaxanthin plays an essential role in protecting the retina of the eye from the damaging effects of light.

From the many carotenoids in the diet, the human retina selectively accumulates only two: zeasanthin and lutein. Their concentration is so high in the macula they are visible as a dark yellow spot called the macular pigment.

Macula pigment has been implicated as a risk factor in age-related macular degeneration (AMD), the most prevalent cause of vision loss in the elderly. Significantly lower macular pigment levels have been found in people with factors known to increase risk for AMD.

An interesting study was recently presented in an ARVO poster that suggests activation of retinal nuclear factor kappa beta (NFkB), an early event in the development of retinopathies, including diabetes-induced oxidative damage, mitochondrial super oxide and nitrative stress in the retina, may be prevented with supplemental zeaxanthin.

A Biosyntrx Editorial on Zeaxanthin and Lutein:

It's important that consumers and eye care professionals become aware that the xanthophyll carotenoids, zeaxanthin and lutein are now being included in formulations (including the AREDs2 formulation) to replace the antioxidant singlet oxygen quenching hydro-carbon carotenoid, beta-carotene. None of the new formulations are including Vitamin A, as retinyl palmitate when they remove the beta-carotene.

Beta-carotene has the ability to convert to retinol, if the vitamin A liver stores are deficient, which they are in many older people. Vitamin A deficiency can be responsible for night driving problems in the older population.

Unfortunately, unlike beta-carotene, zeaxanthin and lutein have almost no ability to convert to Vitamin A retinol, so the science behind the substitution is a bit flawed - since Vitamin A retinol is vital to the health of the retina, specifically the rods and cones.

The best solution: supplement with biochemically balanced amounts of zeaxanthin, lutein, and vitamin A as retinyl palmitate, in a full-spectrum supplement. Additional zeaxanthin or lutein supplementation should be the decision of the consumer and his or her eye care professional.
 
References:

Carotenoid Cation Formation and the Regulation of Photosynthetic Light Harvesting. Holt, N, Zigmantas D, Valkunas L, et al. Science, Vol 307 Issue 5708, 433-436, January 21, 2005 [abstract]

Long term dietary supplementation with zeaxanthin reduces photoreceptor death in light-damaged Japanese quail. Thomson LR, Toyoda Y, et al. Exp Eye Res. 2002 Nov;75(5):529-42. [abstract]

Xanthophylls and Alpha Tocopherol Decrease UVB-Induced Lipid Peroxidation and Stress Signaling in Human Lens Epithelial Cells. Chitchumroonchokchi CK, Bomser JA, et al. J Nutr, 2004 Dec;134(120:3225-3232 [abstract]
* Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Wright ME, Mayne ST, et al. Am J Epidemiol 2004 Jul 1;160(1):68-76 [abstract]
  • QWho holds the patent on zeaxanthin?

    Dennis Geirhart, PhD. The US courts ruled that supplement manufacturers can include up to 4 mg of zeaxanthin in a multiple or disease-specific formulation.

  • QWhat is the recommended daily amount for zeaxanthin?

    At this point RDA for zeaxanthin has not been established.

  • QShould I take more than the 3 and 4 mgs of zeaxanthin you include in Oculair and Macula Complete?

    Dennis Geirhart, PhD, a much admired research scientist and the zeaxanthin patent holder, includes 5 to 20 mg per day in his EyePromise and EyePromise Complete products. It's important to remember that zeaxanthin, unlike beta-carotene, has virtually no ability to convert to Vitamin A retinol, so the eye or macula specific formulations that don't include beta-carotene or Vitamin A, as retinyl palmitate, leave the patient consumer with no supplemental vitamin A, which is particularly necessary for night vision in older people. We recommend that you and your doctor make the decision regarding zeaxanthin supplementation over the 3 and 4 mgs included in Biosyntrx Oculair and Macula Complete.

  • QIs zeaxanthin supplementation safe?

    Zeaxanthin has been granted Generally Recognized As Safe (GRAS) status.

  • QWhy should I supplement with zeaxanthin?

    Zeaxanthin is a powerful antioxidant, as well as the central macula pigment carotenoid preference for UV protection. However, do remember that macula pigment is just one of the issues in the macular degeneration disease process. Zeaxanthin in-vitro studies, yet to be published in peer-reviewed journal, suggest both vascular endothelial growth factor (VEGF) and nuclear factor kappa beta (NFkB) modulation activity in the diabetic eye. A number of plant-based antioxidants, including grape seed and berry anthocyanidins, have already been suggested in published peer-reviewed science to modulate these gene-based transcription factors associated with diseases of the retina - including macular degeneration.